The etiology of diabetic nephropathy （1）2017-01-24 14:10
The etiology of diabetic nephropathy
Is caused by different etiology and pathogenesis of diabetic nephropathy in absolute and relative lack of insulin that sugar, protein and fat metabolism disorders, and chronic high blood sugar as the main clinical manifestations of systemic disease. Diabetes can damage can be made of different ways to damage the kidneys involving the kidney all structures, but only has a direct relationship between glomerular sclerosis and diabetes, also known as diabetic nephropathy, is one of the systemic microvascular complications of diabetes. Diabetes patients condition in the event of kidney damage a persistent proteinuria irreversible tends to develop to end-stage renal failure. Diabetic nephropathy has become the main cause of death in diabetic patients.
Diabetic nephropathy is much in the course of more than 10 years of diabetes, proteinuria is the earliest, diabetic nephropathy pathogenesis is complex, has not been fully elucidated. Research data show that the pathogenesis of diabetic nephropathy is multiple factors, mainly has the following several aspects:
1, the renal hemodynamic abnormalities
Play a key role in diabetic nephropathy, and may even be initiating factors.
(1) high blood sugar, glomerular high perfusion, high filtration state, across the capillary wall pressure increase, expand mesangial cells, epithelial cell foot process fusion, and produce dense droplets, glomerular epithelial cells become detached from the basement membrane. Collagen type (2) the glomerular basement membrane Ⅳ messenger sugar nucleic acid increased, the thickening of basement membrane, finally forms the mesangial diffuse and nodular lesions, glomerular sclerosis.
3) in the case of increased pressure, increase protein filtration, can deposit on the mesangial area and glomerular basement membrane, promote stromal hyperplasia, form a vicious cycle, and can cause nodular and diffuse glomerular sclerosis.