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What is IgA nephropathy? What are the causes?

2017-02-16 15:39

IgA nephropathy, also known as Berger's disease, refers to the glomerular mesangial area with IgA or IgA deposition, with or without other immunoglobulin in the glomerular mesangial area deposition of primary glomerulopathy.

Data show that the incidence of IgA nephropathy in China accounted for 26% - 34% of primary glomerular disease, and in recent years showed a rising trend. However, in clinical, most people do not understand IgA nephropathy, there are many doubts about IgA nephropathy. Here, the small series for one by one interpretation, and gradually uncover the mysterious veil of IgA nephropathy.

From the literal meaning, you can know that IgA nephropathy is a kind of kidney disease, in the end what is IgA nephropathy? I believe many people are only half.

In fact, IgA nephropathy is a group of IgA - or IgA - based immune complexes that are deposited in the glomerular mesangial area or along the kidney - based kidney. It is usually accompanied by hematuria, proteinuria, hypertension, edema, renal dysfunction and other symptoms.

At present, the exact pathogenesis has not been clarified, and many factors play an important role in the pathogenesis of the disease. The pathogenesis of IgA nephropathy generally includes three aspects, namely the formation of sedimentary and pathogenicity of IgA molecules in mesangial area of poly IgA, triggering an inflammatory response glomeruli, leading to the formation and development of IgA nephropathy.

IgA nephropathy is the most common cause of chronic renal insufficiency in our country. The majority of people will be IgA nephropathy as an independent disease, but in fact, due to the pathogenesis of IgA nephropathy and clinical manifestations of the larger changes, should not be used as a single disease, but must be classified.

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