What is the cause of benign hypertensive arteriolar sclerosis?2017-02-02 13:48
Renal sclerosis occurs with age, but can be aggravated by chronic hypertension. The incidence of chronic kidney disease in patients with chronic hypertension is low. Most patients with mild hypertension. However, there are three factors that increase the risk of renal sclerosis: black race, moderate to severe hypertension, and other pre-existing kidney diseases, such as diabetic nephropathy.
Two processes contributed to the occurrence of chronic hypertension and vascular damage: middle hypertrophy and intimal thickening of fiber cell caused by vascular stenosis; secondly, glass like substance (plasma protein components) deposition in the arteriolar wall damage, easy to clear. The most common and specific changes of the afferent arteriole severely affected with hyaline degeneration, internal elastic membrane and basement membrane, and fibrinoid necrosis of the vessel. The inner elastic layer is often damaged and may be layered.
Glomerular may be manifested as focal global and focal segmental glomerulosclerosis. Focal glomerulosclerosis is because of loss of unit ischemic injury and renal function. The focal segmental sclerosis is due to an enlarged glomerulus, which may be a compensatory response to the loss of the nephron. The involvement of vascular and glomerular involvement in the pathogenesis of acute and severe interstitial nephritis associated with ischemia and the active immune process due to altered expression of epithelial cells on the surface of tubules.