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What are the 7 types of IGA nephropathy?

2017-12-05 10:28

40 years ago, Berger reported IgA nephropathy for the first time, and the type of kidney disease was well known. People found the symptoms. This type of nephropathy is various, it can not only the symptoms of occult blood, can also have occult blood + protein, can also be a typical nephrotic syndrome.

Each IgA nephropathy patients are not the same, there are only some occult blood; slow development, about 20% to 25% of the patients after 20 - 25 years after the slow development to uremia; also some rapidly progressive crescentic renal failure occurred in a short time.

The symptoms and prognosis of IgA nephropathy tell us that it is not a single disease, but a group of clinical syndromes.

The type of hematuria under the isolated mirror. The rate of awareness is low, the rate of revisit is poor and the prognosis is better than that of other types.

Repeated hematuria. It is often caused by tonsillar infection, most of which advocate the removal of tonsillar.

Abnormal urine type. Characteristics: the most common clinical, insidious disease, the main manifestation of less to moderate albuminuria, often accompanied by microscopic hematuria. There is no hypertension and normal renal function, but hypertension and renal failure can occur if not actively treated.

Crescent shape. Features: renal biopsy showed glomerular crescentic formation, massive hematuria or continuous gross hematuria, accompanied by hypertension or renal insufficiency. Most patients developed uremia within 4 years.

A large number of albuminuria. Characteristics: typical nephrotic syndrome, without or only a small amount of microscopic hematuria, can have hypertension, renal insufficiency and renal tubular dysfunction.

Treatment: this type of IgA nephropathy, renal tubulointerstitial lesions lighter, can be treated with hormone, if the effect, use hormone to maintain.

But for tubulointerstitial lesions heavier, or patients with renal insufficiency, poor efficacy of hormone or cytotoxic drugs, mainly symptomatic treatment, protect renal function, avoid excessive immunosuppressive treatment of infection and other complications, does not recommend the use of mycophenolate mofetil and cyclophosphamide.

Hypertension type. This is an independent type of IgA nephropathy, and it needs to be defined clearly.

End-stage renal failure type. Renal failure has occurred, irreversible.

In general, there is still a lack of effective treatment for IgA nephropathy in the medical community.


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