What is the manifestation of different degrees of lupus nephritis?2018-01-10 17:05
Different degrees of lupus nephritis what performance, this is the majority of patients with lupus nephritis friends are very concerned about the problem, here to explain to you different degrees of lupus nephritis what performance, I hope we can be helpful.
Symptoms of lupus nephritis may also cause some damage to the kidneys of the patient, and the damage may progressively increase with the patient's condition. Patients with lupus nephritis may experience fever, butterfly erythema and joint soreness. The prognosis of patients with lupus nephritis in different situations is also different. In order to prevent the impact of disease on patients, timely treatment of lupus nephritis.
Lupus nephritis is an immune complex disease that occurs in the body against endogenous antigens and is accompanied by T-cell dysfunction. In lupus nephritis serum can be found in a variety of anti-autologous tissue components of antibodies, including anti-DNA antibodies, especially anti-double-stranded DNA antibodies positive role in patients with circulating immune complexes can be separated into natural and single-stranded DNA antibodies and Antigens; immunoglobulin antibodies that elute from the patient's glomeruli bind to native and single-stranded DNA antigens.
Lupus nephritis can occur at any stage of systemic lupus erythematosus, but generally seen in systemic lupus erythematosus 1-4 years after onset, a very small number of renal disease as the first performance. In addition to clinical patients with fever, butterfly erythema, joint pain and other symptoms of systemic lupus erythematosus, there are clinical manifestations of kidney involvement.
According to the pathological changes of lupus nephritis and prognosis of different clinical manifestations can be divided into four types:
Mild damage accounted for 35% -50%. Clinical symptoms are not obvious, only urine abnormalities, proteinuria is + or + +, or urinary protein less than 1g every 24 hours, microscopic hematuria, normal or mild renal dysfunction, the prognosis is good.
Nephrotic syndrome accounts for about 20%. A typical manifestation of nephrotic syndrome, but normal blood cholesterol, with high blood pressure, moderate renal dysfunction, the prognosis is poor.
Chronic nephritis accounted for 35% -50%. Have high blood pressure, more proteinuria, a large number of red blood cells, renal function was significantly reduced or even renal failure.
Rapid progress in the rapid development of the disease, rapid deterioration of renal function. Urinary protein, increased red blood cell tube, and often accompanied by fever and other lupus activity performance. Often in the short term into renal failure.