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How is uremia caused

2017-02-10 09:19

1, heart, lung water sodium retention, renal ischemia, increased renin secretion caused by long-term effects of hypertension can cause heart failure. The blood urea high into the pericardial and pleural can cause fibrinous pericarditis and cellulose pleurisy, pericardial and pleural friction sound can be heard during auscultation. Heart failure can cause pulmonary edema.

2, patients often have nausea, vomiting, abdominal pain, diarrhea, bloody stool and other symptoms, the main reason is the urea into the digestive tract in vivo accumulation of the digestive system in the intestines to form ammonia by the bacterial urease, can stimulate the gastrointestinal mucosa caused by fibrinous inflammation, ulceration and bleeding even.

3, hematopoietic system is mainly changed to anemia and bleeding.

Anemia cause:
The production of erythropoietin is insufficient in the severe renal tissue damage;
Some metabolites, such as phenol and its derivatives, inhibit the hematopoietic function of bone marrow. Other poisons such as guanidine and its derivatives can shorten the survival period of red blood cells, accelerate the destruction of red blood cells and cause hemolysis.
Excessive loss of transferrin from urine, resulting in the transport of iron in the body.
Uremic patients often have bleeding tendency, manifested as gingival bleeding, epistaxis, hemorrhage of digestive tract.

Causes of bleeding:
Toxic substances inhibit bone marrow, thrombocytopenia.
There are some patients with no reduction in platelet count, but bleeding tendency. This may be due to the role of the blood in the class of guanidine toxicity caused by platelet dysfunction, reduce platelet cohesion and release of platelet factor third decreased.

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